The Immunotherapy Integration Hub (IIH) at Seattle Children’s Research Institute (SCRI) seeks to develop innovative new cellular therapies and translate these advances to groundbreaking clinical trials for children with the most aggressive forms of cancer. We are seeking a bright, enthusiastic, highly-motivated and experienced molecular and cellular biologists to join the Jensen Lab. This position contributes to a team focused on translating tumor immunotherapy from the bench into pediatric patients with cancer. We look for people who are inspired by our mission and who would fit in well with the collaborative, rigorous and entrepreneurial spirit of our research team culture.
The primary purpose of this position is to test a state of the art regulated system for transgene expression to enhance the function of chimeric antigen receptor T cells with the goal of making better clinical therapies. Under the direction of a senior research scientist, the successful candidate will use her/his established molecular/cellular biology skill sets to construct lentiviral or plasmid vectors and create primary T cell lines which contain various transgenes under the regulated system, and evaluate them for regulated effects and biological activities.
The ideal candidate will have significant work experience in molecular biology, immunology, tissue culture and flow cytometry. The candidate will be extensively involved in designing experiments, implementing new strategies, generating data, analyzing results and preparing reports, in support of funded research studies. To ensure successful project completion and teamwork, she/he must have critical thinking abilities, be able to prioritize and perform multiple tasks in a dynamic environment, meet deadlines, and must have excellent written, verbal and interpersonal communication skills. The candidate will be required to participate and present data in weekly lab meetings and maintain up-to-date and well-organized electronic lab notebook.
- Bachelor’s Degree in biology, microbiology, immunology, molecular biology or biochemistry.
- Prior experience in a laboratory setting.
- Research experience in biochemistry, molecular biology, and tissue culture techniques is highly preferred.