The Immunotherapy Integration Hub at Seattle Children’s Research Institute is seeking an ambitious and creative synthetic biologist with direct experience engineering mammalian cells to introduce novel functionality, response, or behavior. The CME specialist will be responsible for the design, molecular assembly, and early characterization of cutting-edge T-cell engineering constructs which will be directly placed in an intensive developmental pipeline aimed at rapid clinical translation of transformative therapies. Communication of your results regularly to both internal and external stakeholders will be required, as will be keeping pace with current literature in cell therapy.
The pace of the work will be demanding, and your impact will be substantial for the pediatric cancer patients whom your work directly benefits. Success in this position will directly result in translation of these next-generation technologies into Phase I clinical trials at Seattle Children’s, with the possibility to expand into multi-site international trials, saving children all over the world.
Primary responsibilities of this job will be to bolster the creative pipeline of the Molecular Engineering Team by designing and implementing novel cell engineering concepts developed by you and your team, in a strict GLP environment. The candidate will be expected to utilize both the scientific literature and their own cell and molecular engineering prowess to create new and highly impactful parts and systems for T-cell engineering, transforming cell therapy as we know it and saving lives in the process.
The ideal candidate will be from an immunology, molecular biology, cell biology, or related background. Desired, but not required are direct experience with engineering T-cells or other primary immune cells and diverse experience with cell engineering tools (mRNA, linear/circular plasmid DNA, viral vectors, etc.). This is a highly creative position and the successful candidate will highlight their abilities with their CV and cover letter.
- PhD in molecular or cellular biology, biochemistry, or a related area with thesis work in synthetic biology/cell engineering required.
- Minimum of three (3) years experience in a related area of scientific study.
- Experience analyzing data using imaging software.
- Experience with laboratory coordination.
- Substantial prior experience in biochemistry, molecular biology, and tissue culture techniques