• Research Scientist III-Process and Analytical Development

    Job ID 2018-29195
    Area of Interest
    Research & Development
    Location Name
    Metropolitan Park West
    FTE/Hours per pay period
    1.0 FTE (80 hours per bi-weekly pay periods)
    Work Status
    Immunotherapy Integration Hub
    Day Shift
  • Overview

    The Immunotherapy Integration Hub is a brand new, dynamic center at Seattle Children’s Research Institute seeking to revolutionize the treatment of childhood cancers by assembling a unique team of experts in the field of cellular therapeutics to provide translational services to partner institutions across the globe. An integral piece of this organization is the Therapeutic Innovation Core, responsible for early stage R+D, Preclinical development, and GMP process development for cutting-edge cell therapies.
    The hired candidate will be part of the Process and Analytical Development division within TIC. The PAD group is dedicated to optimizing manufacturing engineered cell therapies from all angles, to increase quality and efficiency, control cost, and cure more patients. The work we do is highly cross-disciplinary, intensely collaborative, and immensely impactful. Every advance we make in product quality means more remissions, every dollar we save on process cost means more patients can be treated. We need a team member who will be motivated by the importance of this work to overcome highly challenging problems with innovative solutions, and who is versatile enough to handle working in, technologically speaking, a no-holds-barred environment.
    This position will cover two main project areas: Establishment and optimization of enhanced cellular analytics platforms, and Process Development work for lentiviral vector preparation.
    Cellular analyses will include functional in vitro testing to assess the efficacy of therapeutics, in addition to deep genetic analysis, flow cytometry, metabolic characterization, immunological assays, and more. In many cases the most effective and appropriate analyses for cell therapies are unknown and the candidate will work with the PAD and Correlative Studies teams to blaze new trails in the field.
    Additionally, the PAD group is taking on the development of a state-of-the-art lentiviral vector manufacturing process, which when complete will allow SCRI researchers to move their therapies towards the clinic at speed and cost efficiency that was never before possible. This position will support both upstream and downstream PD efforts and will gain extremely valuable experience in a rapidly growing field of biomanufacturing.


    Required Education/Experience:
    - PhD in molecular or cellular biology, bioengineering, or thesis work in a similar field.
    - Minimum of three (3) years experience in a related area of scientific study.
    - Experience analyzing data using imaging software.
    - Experience with laboratory coordination.

    - Substantial prior experience in biochemistry, molecular biology, and tissue culture techniques


    *Please send a CV with three references, and a non-generic cover letter describing what you can bring to the table for this specific job and how who you are as a person will make you an ideal candidate to join our team, to joshua.gustafson@seattlechildrens.org.*


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