The malaria research lab of Dr. Ashley Vaughan (www.seattlechildrens.org/research/centers-programs/global-infectious-disease-research/research-areas-and-labs/vaughan-lab/) at the Center for Global Infectious Disease Research (CGIDR) at Seattle Children’s Research Institute (SCRI) is recruiting a Postdoctoral Scientist to study malaria parasites. This NIH-funded project aims to elucidate how protein glycosylation modulates the ability of the parasite to invade and infect host organisms. The work will be carried out in the human-infective parasite Plasmodium falciparum using in vitro and in vivo infection models covering the entire parasite life cycle.
This position offers an extraordinary opportunity to work in a collaborative, multi-disciplinary environment. The project is a collaboration between Dr. Vaughan and Dr. Kristian Swearingen (www.isbscience.org/bio/kristian-swearingen-phd/) of the Institute for Systems Biology (ISB), who will co-mentor the successful applicant. The primary responsibility of the position will be studies into the molecular parasitology of Plasmodium, including culturing parasites, producing transgenic parasite lines, and characterizing phenotypes. This work will be performed in the joint laboratories of Dr. Vaughan and Dr. Stefan Kappe (www.seattlechildrens.org/research/centers-programs/global-infectious-disease-research/research-areas-and-labs/kappe-lab/) at CGIDR, which comprises a large, multidisciplinary team that will provide training in cutting-edge molecular parasitology techniques. The project includes mass spectrometry-based proteomic analysis of the parasites, which will be performed in collaboration with Dr. Swearingen. The successful applicant will have Visiting Scientist status at ISB in the laboratories of Dr. Swearingen and Dr. Rob Moritz (www.isbscience.org/bio/robert-moritz-phd/) and will have the opportunity to learn systems biology and proteomics skills in addition to their molecular parasitology training.
The successful candidate will have a keen interest in working with Plasmodium as a parasite of global health importance, basic parasite biology, and the translation of novel findings into approaches for intervention.
Job responsibilities will include:
Along with a curriculum vitae, candidates must provide a cover letter detailing the following:
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