Fellow - PhD, Research

Job ID 2020-35835
Area of Interest
Research & Development
Location Name
307 Westlake
FTE/Hours per pay period
1.0 FTE (80 hours per bi-weekly pay periods)
Work Status
Regular
Department
Global Infectious Disease
Shift
Day Shift
Primary Location : City
Seattle
Primary Location : State/Province
WA

Overview

The malaria research lab of Dr. Ashley Vaughan (www.seattlechildrens.org/research/centers-programs/global-infectious-disease-research/research-areas-and-labs/vaughan-lab/) at the Center for Global Infectious Disease Research (CGIDR) at Seattle Children’s Research Institute (SCRI) is recruiting a Postdoctoral Scientist to study malaria parasites. This NIH-funded project aims to elucidate how protein glycosylation modulates the ability of the parasite to invade and infect host organisms. The work will be carried out in the human-infective parasite Plasmodium falciparum using in vitro and in vivo infection models covering the entire parasite life cycle.

 

This position offers an extraordinary opportunity to work in a collaborative, multi-disciplinary environment. The project is a collaboration between Dr. Vaughan and Dr. Kristian Swearingen (www.isbscience.org/bio/kristian-swearingen-phd/) of the Institute for Systems Biology (ISB), who will co-mentor the successful applicant. The primary responsibility of the position will be studies into the molecular parasitology of Plasmodium, including culturing parasites, producing transgenic parasite lines, and characterizing phenotypes. This work will be performed in the joint laboratories of Dr. Vaughan and Dr. Stefan Kappe (www.seattlechildrens.org/research/centers-programs/global-infectious-disease-research/research-areas-and-labs/kappe-lab/) at CGIDR, which comprises a large, multidisciplinary team that will provide training in cutting-edge molecular parasitology techniques. The project includes mass spectrometry-based proteomic analysis of the parasites, which will be performed in collaboration with Dr. Swearingen. The successful applicant will have Visiting Scientist status at ISB in the laboratories of Dr. Swearingen and Dr. Rob Moritz (www.isbscience.org/bio/robert-moritz-phd/) and will have the opportunity to learn systems biology and proteomics skills in addition to their molecular parasitology training.

 

The successful candidate will have a keen interest in working with Plasmodium as a parasite of global health importance, basic parasite biology, and the translation of novel findings into approaches for intervention.

 

Job responsibilities will include:

  • Producing Plasmodium falciparum parasites at multiple stages, including blood stages and mosquito stages
  • Producing transgenic parasite lines
  • Performing data analysis and presenting research at internal meetings, scientific conferences, and in peer-reviewed scientific manuscripts

Along with a curriculum vitae, candidates must provide a cover letter detailing the following:

  • Interest in working on the malaria parasite
  • What they hope to achieve during their tenure in this position
  • Scientific career ambitions and research goals
  • Any other important information not covered by the CV (e.g. gaps in research or education due to family responsibilities or extenuating circumstances).

Hope. Care. Cure. These three simple words capture what we do at Seattle Children’s – to help every child live the healthiest and most fulfilling life possible.  Are you ready to engage with a mission-driven organization that is life-changing to many, and touches the hearts of all? #HOPECARECURE

 

As one of the nation's top five pediatric research centers, Seattle Children's Research Institute is dedicated to providing hope, care, and cures to help every child live the healthiest and most fulfilling life possible.

 

Our investigators are involved in hundreds of projects that cover every phase of research, from studying how diseases work to improving investigational therapies. They have pioneered groundbreaking cystic fibrosis treatments and cutting-edge cancer therapies that help a child's immune system defeat cancer, and made other major contributions to pediatric medicine. 

 

Researchers work in close collaboration with one another, their colleagues at partner institutions including the University of Washington and Fred Hutch and our healthcare providers at Seattle Children's Hospital, one of U.S. News & World Report’s top children's hospitals. This collaboration is one of our key strengths, allowing our faculty to draw on a variety of disciplines and techniques as they pursue solutions to some of medicine's most complex problems.

 

We are committed to not only treating disease but to eliminating it. Help us achieve our vision of being a worldwide leader in pediatric research aimed to improve the health and well-being of children. If you are interested in a challenging career aimed at groundbreaking research, Seattle Children's Research Institute is the place for you.

 

 

Requirements

Required Qualifications:

  • Ph.D. in molecular biology or a related scientific discipline
  • Experience in cell biology, molecular biology, or molecular genetics laboratory technique (e.g. cell culture, PCR, microscopy)
  • Willingness to work with a diverse team of scientists, including postdocs, students and technicians.
  • The ability to work independently as well as collaboratively

Beneficial qualifications (not required)

  • Experience working with infectious disease models, especially apicomplexan parasites

Our Commitment to Diversity

Our community welcomes diverse experiences, backgrounds, and thoughts as this is what drives our spirit of inquiry and allows us to better connect with our increasingly diverse patients and families. Our organization recruits, employs, trains, compensates, and promotes without regard to race, religion, color, national origin, gender (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, age, status as a protected veteran, status as an individual with a disability, or other applicable legally protected characteristics.

 

The people who work at Seattle Children’s are members of a community that seeks to respect and celebrate all the qualities that make each of us unique. Each of us is empowered to be ourselves within this community, which cultivates and promotes equity, diversity, and inclusion at all levels.

 

Seattle Children’s is proud to be an Equal Opportunity Workplace and Affirmative Action Employer.

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