Postdoctoral Fellow - Paquette Lab

Job ID 2020-36047
Area of Interest
Research & Development
Location Name
Jack R MacDonald Building
FTE/Hours per pay period
1.0 FTE (80 hours per bi-weekly pay periods)
Work Status
Dev Biology & Regenerative Med
Day Shift
Primary Location : City
Primary Location : State/Province

About Us

Hope. Care. Cure. These three simple words capture what we do at Seattle Children’s – to help every child live the healthiest and most fulfilling life possible.  Are you ready to engage with a mission-driven organization that is life-changing to many, and touches the hearts of all? #HOPECARECURE


As one of the nation's top five pediatric research centers, Seattle Children's Research Institute is dedicated to providing hope, care, and cures to help every child live the healthiest and most fulfilling life possible.


Our investigators are involved in hundreds of projects that cover every phase of research, from studying how diseases work to improving investigational therapies. They have pioneered groundbreaking cystic fibrosis treatments and cutting-edge cancer therapies that help a child's immune system defeat cancer, and made other major contributions to pediatric medicine. 


Researchers work in close collaboration with one another, their colleagues at partner institutions including the University of Washington and Fred Hutch and our healthcare providers at Seattle Children's Hospital, one of U.S. News & World Report’s top children's hospitals. This collaboration is one of our key strengths, allowing our faculty to draw on a variety of disciplines and techniques as they pursue solutions to some of medicine's most complex problems.


The Paquette lab at the Center for Developmental Biology and Regenerative Medicine, Seattle Children’s Research Institute and the University of Washington invites applications for a postdoctoral position. Pregnancy and the perinatal period represent a transient but crucial time in an individual’s life that has a lifelong impacts on human health. The placental is a crucial mediator of the in-utero environment, and perturbations to placental function may influence fetal growth and development. Dr. Paquettes’ lab studies the underlying molecular mechanisms linking the in utero environment and birth outcomes by applying innovative network biology approaches and multi-omic data analysis within the placenta. Immediate (funded) projects in the lab involve analysis of how maternal stress, CRH and phthalates disrupt the placental transcriptome. There will be opportunities to build upon these research questions to investigates other exposures and infant health outcomes; as well as to generate and integrate more omics data in key pregnancy tissues.


This lab is an ideal place for a postdoctoral candidate because of the highly interdisciplinary nature of our work, collaborations across the UW community and beyond, and opportunity to develop unique projects within this space. Our lab is well funded by multiple grants, providing ample resources to pursue cutting edge science and advance your career. The PI is committed to career development of trainees, and you will receive strong mentorship and be provided with opportunities to present your research locally as well as at national meetings. There are ample opportunities to develop a strong computational background within SCRI; as the Research Informatics team provides regular classes on key concepts in this field and holds routine office hours. Seattle is a hub for bioinformatics and computational biology research, and are ample opportunities to attend seminars and interface across the University of Washington; as well as from organizations such as the Brotman Baty Institute and the Pacific Northwest Metabolomics core. The selected candidate will join the vibrant research community at CDBRM, located in a newly renovated building in downtown Seattle. A modern, open lab space, a collegial atmosphere, on-site gym and rooftop garden, and top-of-the-line equipment, office space and meeting rooms make this an ideal training environment. Initial appointment will be for one year, with extension contingent on funding and performance.


Successful candidates should be highly motivated with an outstanding publication record (at least one first-author research paper published in peer-reviewed international journal) and strong work ethic. The candidate will be expected to independently move projects forward, write papers, and apply for F32 or equivalent grants. Our research is highly interdisciplinary, and we will consider candidates across a broad range of research backgrounds. Dedication and experience with environmental exposures, reproductive biology, computational biology, or placental biology are high priority areas. The work is primarily computational, but experimental validation of findings working within placental cell lines will be performed; so expertise with cell culture would be valuable. Prior experience working with the R programming language and formal training biostatics and/or epidemiology would be valuable as well.


To apply for this position; please provide a (1) curriculum vitae and (2) a cover letter detailing your research goals, interest in working within the perinatal biology space, and any other information that is not covered in the CV that may be relevant.




Required Education/Experience

  • PhD in specialty area from an accredited university training program
  • Experience using basic research techniques of specialty area
  • Prior Experience with drafting and submitting manuscripts to peer reviewed journals.


Preferred Education/Experience:

  • Formal training biostatistics and/or epidemiology
  • Research background in environmental exposure analysis, perinatal/placental/reproductive biology, or molecular biology
  • Experience with working with the R programming language and on high throughput bioinformatics data
  • Experience using basic research techniques in molecular biology

Our Commitment to Diversity

Our community welcomes diverse experiences, backgrounds, and thoughts as this is what drives our spirit of inquiry and allows us to better connect with our increasingly diverse patients and families. Our organization recruits, employs, trains, compensates, and promotes without regard to race, religion, color, national origin, gender (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, age, status as a protected veteran, status as an individual with a disability, or other applicable legally protected characteristics.


The people who work at Seattle Children’s are members of a community that seeks to respect and celebrate all the qualities that make each of us unique. Each of us is empowered to be ourselves within this community, which cultivates and promotes equity, diversity, and inclusion at all levels.


Seattle Children’s is proud to be an Equal Opportunity Workplace and Affirmative Action Employer.


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