Postdoctoral Fellow - PhD

Job ID 2020-36302
Area of Interest
Research & Development
Location Name
Jack R MacDonald Building
FTE/Hours per pay period
1.0 FTE (80 hours per bi-weekly pay periods)
Work Status
Regular
Department
Immunity & Immunotherapies
Shift
Day Shift
Primary Location : City
Seattle
Primary Location : State/Province
WA

About Us

Hope. Care. Cure. These three simple words capture what we do at Seattle Children’s – to help every child live the healthiest and most fulfilling life possible.  Are you ready to engage with a mission-driven organization that is life-changing to many, and touches the hearts of all? #HOPECARECURE

 

As one of the nation's top five pediatric research centers, Seattle Children's Research Institute is dedicated to providing hope, care, and cures to help every child live the healthiest and most fulfilling life possible.

 

Our investigators are involved in hundreds of projects that cover every phase of research, from studying how diseases work to improving investigational therapies. They have pioneered groundbreaking cystic fibrosis treatments and cutting-edge cancer therapies that help a child's immune system defeat cancer, and made other major contributions to pediatric medicine. 

 

Researchers work in close collaboration with one another, their colleagues at partner institutions including the University of Washington and Fred Hutch and our healthcare providers at Seattle Children's Hospital, one of U.S. News & World Report’s top children's hospitals. This collaboration is one of our key strengths, allowing our faculty to draw on a variety of disciplines and techniques as they pursue solutions to some of medicine's most complex problems.

 

We are committed to not only treating disease but to eliminating it. Help us achieve our vision of being a worldwide leader in pediatric research aimed to improve the health and well-being of children. If you are interested in a challenging career aimed at groundbreaking research, Seattle Children's Research Institute is the place for you.

Overview

The Acharya lab (www.seattlechildrens.org/directory/mridu-acharya) at Seattle Children’s Research Institute is hiring a motivated post-doctoral scientist to join a rapidly expanding research program focused on immune signaling pathways that regulate the balance between protective immunity to viruses while preventing development of autoimmunity. We also collaborate with the James lab and Rawlings lab at Seattle Children’s to use gene editing technology in B cells to manipulate genes and study changes in antibody responses. For this position, we are seeking a scientist to work on a project related to understanding how integrin signaling and autophagy proteins regulate immune response to influenza virus. The applicant is expected to have skills in methods such flow cytometry,  and tissue culture experiments. Applicant will be expected to work with mice and with target tissues harvested from mice as well as use human PBMC samples for some experiments. Experience in using microscopy to study intracellular localization of proteins or using biochemistry methods to study cell biology would be higly preferred. The applicant will be responsible for data anlalysis, presentation of results and collaborating with other scientists in the group.

 

KEY RESPONSIBILITIES:

  1. Design experiments to study activation of signaling pathways in B cells of the immune system, using flow cytometry and western blot.
  2. Design and perform experiments to study immune response to influenza virus in mice.
  3. Use assays such as ELISA and ELISPOT to study development of antibody response.
  4. Assist with management of mouse colony.
  5. Use mouse models to study development of autoimmunity.
  6. Harvest tissues from mice to study different immune cell populations using flow-cytometry.
  7. Analyse data and present data at group meetings.
  8. Contribute to writing for publication of results; generate figures for papers and grants.

 

#LI-TD1

Requirements

Required Education/Experience:

- Required PhD in Immunology or related field

- Experience using basic research techniques of specialty area

Preferred:
- Previous experience conducting research in the pediatric arena
- Experience in protocol and manuscript development and in grant writing

Our Commitment to Diversity

Our community welcomes diverse experiences, backgrounds, and thoughts as this is what drives our spirit of inquiry and allows us to better connect with our increasingly diverse patients and families. Our organization recruits, employs, trains, compensates, and promotes without regard to race, religion, color, national origin, gender (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, age, status as a protected veteran, status as an individual with a disability, or other applicable legally protected characteristics.

 

The people who work at Seattle Children’s are members of a community that seeks to respect and celebrate all the qualities that make each of us unique. Each of us is empowered to be ourselves within this community, which cultivates and promotes equity, diversity, and inclusion at all levels.

 

Seattle Children’s is proud to be an Equal Opportunity Workplace and Affirmative Action Employer.

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