Research Scientist I - EX

Job ID 2021-38029
Area of Interest
Research & Development
Location Name
307 Westlake
FTE/Hours per pay period
1.0 FTE (80 hours per bi-weekly pay periods)
Work Status
Global Infectious Disease
Day Shift
Primary Location : City
Primary Location : State/Province

About Us

Hope. Care. Cure. These three simple words capture what we do at Seattle Children’s – to help every child live the healthiest and most fulfilling life possible.  Are you ready to engage with a mission-driven organization that is life-changing to many, and touches the hearts of all? #HOPECARECURE


As one of the nation's top five pediatric research centers, Seattle Children's Research Institute is dedicated to providing hope, care, and cures to help every child live the healthiest and most fulfilling life possible.


Our investigators are involved in hundreds of projects that cover every phase of research, from studying how diseases work to improving investigational therapies. They have pioneered groundbreaking cystic fibrosis treatments and cutting-edge cancer therapies that help a child's immune system defeat cancer, and made other major contributions to pediatric medicine. 


Researchers work in close collaboration with one another, their colleagues at partner institutions including the University of Washington and Fred Hutch and our healthcare providers at Seattle Children's Hospital, one of U.S. News & World Report’s top children's hospitals. This collaboration is one of our key strengths, allowing our faculty to draw on a variety of disciplines and techniques as they pursue solutions to some of medicine's most complex problems.


We are committed to not only treating disease but to eliminating it. Help us achieve our vision of being a worldwide leader in pediatric research aimed to improve the health and well-being of children. If you are interested in a challenging career aimed at groundbreaking research, Seattle Children's Research Institute is the place for you.


A technical scientist position is available in the Translational Immunology Group.  The successful candidate will possess a passion for science, and a desire to advance the understanding and treatment of epidemic- and  pandemic-prone diseases. The candidate will be involved in characterizing functionality of immune cells in the context of positive strand RNA viruses e.g., SARS-CoV-2, tuberculosis and nontuberculous mycobacteria.  Previous experience in human immunology and cellular immunoassays, including multiparametric flow cytometry, is required.  The candidate should have experience with and be willing to work with mouse models and should be comfortable with the handling of human blood and tissue samples. A highly organized and self-directed individual with strong interpersonal skills and the ability to work in a dynamic environment is desired.


Primary Responsibilities:

  • Assist the clinical immunology group in assessment of immunological endpoints in vaccine clinical trials including assay development and validation.
  • Contribute to study designs, clinical study reports, statistical analysis plans, manuscripts, and grant applications.
  • Perform specimen processing, and shipping for domestic and international sites.
  • Design and execute research projects that further the understanding and development of effective vaccines.
  • Responsible for developing immunoassay methodology following scientific literature review, quality standards and discussion with peers, as required.
  • Responsible for preparing Standard Operating Procedures and development/optimization/ qualification/validation reports for immunoassays.
  • Responsible for performing assay development, optimizations, and validations in collaboration with others.
  • Participate in laboratory audits to ensure GCLP-like compliance and assist with clinical training activities.
  • Records procedures, outcomes and observations in lab notebook following established guidelines.
  • Utilize established mathematical and scientific techniques to compile, critically analyze and interpret data.
  • Communicate with research management on a regular basis.
  • Prepare manuscripts for publication in peer reviewed journals.
  • Present research at group and internal/external scientific meetings.
  • Contributes to or leads maintenance of the sample repository including sample tracking procedures.
  • Supervision of research assistant(s) and/or associate(s).


Required Education/Experience:
- Bachelor’s Degree in biology, microbiology, immunology, molecular biology or biochemistry.
- Prior experience in a laboratory setting.


  • A BSc and/or MSc in immunology or related discipline and a minimum of 2 years of related research experience.
  • Experience in microbiology and/or infectious diseases.
  • Experience with Good Clinical Laboratory Practice.
  • Experience and skills with PBMC processing, humoral, and/or cellular immunology and human T- and B-cell based functional assays (e.g., ELISpot, ELISA and antibody neutralization).
  • Experience in one or more of the following areas: clinical trials, project management, assay development, assay validation, generating budgets for laboratory procedures, training clinical sites on specimen processing (domestic and international), repository management, management of research associates
  •  A strong publication track record.
  • Preference will be given to candidates with extensive experience in >12-color flow cytometry panels and cutting-edge biomarker techniques.
  • Experience working under Biosafety Level 2 or 3 (BSL-2/BSL-3) conditions.
  • Excellent oral and written communication skills in English.
  • Proficiency in MS Office, scientific data/graphics programs, and biostatistics.
  • Must be self-motivated, highly organized and able to work in a team environment.


In accordance with new Washington law for healthcare workers, Seattle Children’s requires that all staff be fully vaccinated against COVID-19 on or before October 18, 2021, or before beginning employment for start dates after October 18th.

Our Commitment to Diversity

Our community welcomes diverse experiences, backgrounds, and thoughts as this is what drives our spirit of inquiry and allows us to better connect with our increasingly diverse patients and families. Our organization recruits, employs, trains, compensates, and promotes without regard to race, religion, color, national origin, gender (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, age, status as a protected veteran, status as an individual with a disability, or other applicable legally protected characteristics.


The people who work at Seattle Children’s are members of a community that seeks to respect and celebrate all the qualities that make each of us unique. Each of us is empowered to be ourselves within this community, which cultivates and promotes equity, diversity, and inclusion at all levels.


Seattle Children’s is proud to be an Equal Opportunity Workplace and Affirmative Action Employer.


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