Research Scientist III - Regulatory T Cell

Job ID 2021-41052
Area of Interest
Research & Development
Location Name
Jack R MacDonald Building
FTE/Hours per pay period
1.0 FTE (80 hours per bi-weekly pay periods)
Work Status
Immunity & Immunotherapies
Day Shift
Primary Location : City
Primary Location : State/Province

About Us

Hope. Care. Cure. These three simple words capture what we do at Seattle Children’s – to help every child live the healthiest and most fulfilling life possible.  Are you ready to engage with a mission-driven organization that is life-changing to many, and touches the hearts of all? #HOPECARECURE


As one of the nation's top five pediatric research centers, Seattle Children's Research Institute is dedicated to providing hope, care, and cures to help every child live the healthiest and most fulfilling life possible.


Our investigators are involved in hundreds of projects that cover every phase of research, from studying how diseases work to improving investigational therapies. They have pioneered groundbreaking cystic fibrosis treatments and cutting-edge cancer therapies that help a child's immune system defeat cancer, and made other major contributions to pediatric medicine. 


Researchers work in close collaboration with one another, their colleagues at partner institutions including the University of Washington and Fred Hutch and our healthcare providers at Seattle Children's Hospital, one of U.S. News & World Report’s top children's hospitals. This collaboration is one of our key strengths, allowing our faculty to draw on a variety of disciplines and techniques as they pursue solutions to some of medicine's most complex problems.


We are committed to not only treating disease but to eliminating it. Help us achieve our vision of being a worldwide leader in pediatric research aimed to improve the health and well-being of children. If you are interested in a challenging career aimed at groundbreaking research, Seattle Children's Research Institute is the place for you.


Join groundbreaking research engineering antigen-specific regulatory T cell therapies in the beautiful Pacific Northwest. We are seeking an experienced laboratory scientist with interests in adoptive T cell therapies, gene editing, and basic or translational immunology to participate in reseach focused on generating and testing engineered T regulatory cells (EngTregs) to treat autoimmune disorders.  The candidate will join a robust, established team that is expanding upon a novel immunotherapy platform (see for example PMID: 32493794).  We are in downtown Seattle, a city that is surrounded by lakes, the Puget Sound, and the Cascade and Olympic mountains- a great location for both urban and outdoor adventurers.  The projects are collaborative and supported by biotech, NIH, and institutional funding sources, and the laboratory is led by Dr. David Rawlings, Director of  the Center for Immunity and Immunotherapies at the Seattle Children's Research Institute.


Job Responsibilities:

  • Design, execute and interpret experiments to generate and test novel immune therapies.
  • Develop and refine in vitro assays and in vivo models to evaluate cellular products.
  • Present data at internal and external meetings and contribute data to manuscripts and patents.
  • Think critically, trouble shoot, and problem solve.
  • Be comfortable in fast paced environment and able to work collaboratively.
  • Have excellent interpersonal, verbal and written communication skills.
  • Manage and mentor junior scientists.
  • Have strong hands-on expertise in molecular biology, cell culture, assay development, and/or flow cytometry analysis. Treg biology and animal model expertise is highly desired.


Required Education/Experience:
- PhD Degree level in Biochemistry or related field OR
- Master's Degree in Biochemistry or related field plus minimum three (3) years of related experience OR
- Bachelor's Degree or higher in Biochemistry or related field plus minimum five (5) years of related experience with a strong publication record
- Related work experience must include the following:
- Documented experience in Mass Spectrometry-based Proteomics to identify host-factors of microbial infections

- PhD in molecular or cellular biology, biochemistry, neuroscience, or a related area
- Substantial prior experience in biochemistry, molecular biology, and tissue culture techniques
- Familiarity with mouse brain development.

In accordance with new Washington law for healthcare workers, Seattle Children’s requires that all staff be fully vaccinated against COVID-19 on or before October 18, 2021, or before beginning employment for start dates after October 18th.

Covid-19 Vaccination

In accordance with Washington state law, Seattle Children’s requires that all employees be fully vaccinated against COVID-19. All offers are contingent and your vaccine status will be verified at onboarding.

Our Commitment to Diversity

Our community welcomes diverse experiences, backgrounds, and thoughts as this is what drives our spirit of inquiry and allows us to better connect with our increasingly diverse patients and families. Our organization recruits, employs, trains, compensates, and promotes without regard to race, religion, color, national origin, gender (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, age, status as a protected veteran, status as an individual with a disability, or other applicable legally protected characteristics.


The people who work at Seattle Children’s are members of a community that seeks to respect and celebrate all the qualities that make each of us unique. Each of us is empowered to be ourselves within this community, which cultivates and promotes equity, diversity, and inclusion at all levels.


Seattle Children’s is proud to be an Equal Opportunity Workplace and Affirmative Action Employer.


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