Research Scientist II

Job ID 2021-42150
Area of Interest
Research & Development
Location Name
Jack R MacDonald Building
FTE/Hours per pay period
1.0 FTE (80 hours per bi-weekly pay periods)
Work Status
Regular
Department
Immunity & Immunotherapies
Shift
Day Shift
Primary Location : City
Seattle
Primary Location : State/Province
WA

About Us

Hope. Care. Cure. These three simple words capture what we do at Seattle Children’s – to help every child live the healthiest and most fulfilling life possible.  Are you ready to engage with a mission-driven organization that is life-changing to many, and touches the hearts of all? #HOPECARECURE

 

As one of the nation's top five pediatric research centers, Seattle Children's Research Institute is dedicated to providing hope, care, and cures to help every child live the healthiest and most fulfilling life possible.

 

Our investigators are involved in hundreds of projects that cover every phase of research, from studying how diseases work to improving investigational therapies. They have pioneered groundbreaking cystic fibrosis treatments and cutting-edge cancer therapies that help a child's immune system defeat cancer, and made other major contributions to pediatric medicine. 

 

Researchers work in close collaboration with one another, their colleagues at partner institutions including the University of Washington and Fred Hutch and our healthcare providers at Seattle Children's Hospital, one of U.S. News & World Report’s top children's hospitals. This collaboration is one of our key strengths, allowing our faculty to draw on a variety of disciplines and techniques as they pursue solutions to some of medicine's most complex problems.

 

We are committed to not only treating disease but to eliminating it. Help us achieve our vision of being a worldwide leader in pediatric research aimed to improve the health and well-being of children. If you are interested in a challenging career aimed at groundbreaking research, Seattle Children's Research Institute is the place for you.

Overview

The James lab at Seattle Children’s Research Institute (SCRI) is hiring motivated scientists to join a rapidly expanding research program focused on B cell engineering. The ultimate goal of the B cell engineering group is to develop novel cell therapies that provide sustained production of therapeutic proteins from gene-edited, adoptively transferred, autologous plasma B cells. Learn more about the SCRI B cell program here: https://vimeo.com/646051754

 

For this position, we are seeking a highly motivated aspiring biologist to participate in projects in the primary B cell engineering and differentiation sub-group. Specifically, the successful candidate will lead experiments focused on the development and assessment of allogeneic human B cells. The candidate will culture and engineer primary B cells to express proteins that prevent an immune response targeting the engineered cells. The resulting cell product will be transferred to an animal model and containing MHC mismatched immune cells. Survival of these cells will be assessed following sacrifice using flow cytometry and ELISA.

 

The applicant will collaborate with senior scientists and the principal investigators to plan, execute and interpret experiments. The applicant will be required to independently select and apply standardized scientific procedures, contribute to the design and planning of experiments, troubleshoot experiments, make detailed observations, record data and assist in the preparation of reports, papers and presentations. In this role, the research scientist will be involved with both cell biology applications and in rodent experiments.  

Requirements

Required Education/Experience:

- Bachelor’s Degree in an engineering or scientific discipline; may require a Master’s Degree for certain lab specialties

- Minimum to two (2) year’s experience in a related area/laboratory setting.


Preferred:

- Master’s Degree in molecular biology is highly preferred

- Expertise in animal handling and in vivo cell transfers

- Expertise with flow cytometry of immune cells

- Some experience with laboratory management.

- Evidence of recent publication

 

In accordance with new Washington law for healthcare workers, Seattle Children’s requires that all staff be fully vaccinated against COVID-19 on or before October 18, 2021, or before beginning employment for start dates after October 18th.

Covid-19 Vaccination

In accordance with Washington state law, Seattle Children’s requires that all employees be fully vaccinated against COVID-19. All offers are contingent and your vaccine status will be verified at onboarding.

Our Commitment to Diversity

Our community welcomes diverse experiences, backgrounds, and thoughts as this is what drives our spirit of inquiry and allows us to better connect with our increasingly diverse patients and families. Our organization recruits, employs, trains, compensates, and promotes without regard to race, religion, color, national origin, gender (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, age, status as a protected veteran, status as an individual with a disability, or other applicable legally protected characteristics.

 

The people who work at Seattle Children’s are members of a community that seeks to respect and celebrate all the qualities that make each of us unique. Each of us is empowered to be ourselves within this community, which cultivates and promotes equity, diversity, and inclusion at all levels.

 

Seattle Children’s is proud to be an Equal Opportunity Workplace and Affirmative Action Employer.

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