Postdoctoral Fellow - Jackson Lab

POSTDOCTORAL FELLOWSHIP POSITION:

The Jackson laboratory (Jackson Lab (seattlechildrens.org) at Seattle Children’s Research Institute (SCRI) is seeking a motivated postdoctoral fellow to work on projects focused on the pathogenesis and treatment of systemic autoimmunity. The postdoctoral scientist would join a rapidly expanding research program in B cell biology within the Center for Immunity and Immunotherapies at SCRI.(Center for Immunity and Immunotherapies (seattlechildrens.org).

Within this broad research focus, specific projects could include:
1) Delineating the B cell-specific drivers of humoral autoimmunity, in particular systemic lupus erythematosus (SLE).
2) Interrogating the pathogenesis of human lupus nephritis using cutting-edge single cell and spatial transcriptomics.
3) Novel therapeutic strategies for B cell depletion in systemic autoimmunity, including design of bispecific antibodies and drug-regulatable chimeric antigen receptor (CAR) T cells. The overall goal of this project would be to both develop new treatments for SLE and to gain mechanistic insights into lupus pathophysiology via the targeted depletion of specific B cell subpopulations.

For this position, we are seeking a highly motivated scientist to work with the group in performing experiments related to murine modeling of humoral autoimmunity, flow cytometry, ELISA, tissue culture experiments, and viral transduction. Experiments will also involve animal models of disease, include immunisation of mice and harvesting target tissues from mice.

We are looking for an individual who is enthusiastic about taking a hands-on, problem-solving approach, can think analytically, and enjoys working in a collaborative group setting. Most of the responsibilities will be project driven and the candidate is expected to be able to exercise independent judgment in designing and conducting experiments in a rapidly changing, deadline-driven environment. Must be able to interpret, evaluate, analyze, and present data/progress through individual and group meetings as well as accurately document and record experiments in an electronic lab notebook (ELN). Must possess a professional demeanor and excellent verbal, written, interpersonal and organizational skills, as well as the ability to multitask and troubleshoot various issues.

Applicants must possess a Ph.D. or equivalent and should have a strong background in immunology or cell biology.

Interested individuals should send a curriculum vitae and a brief summary of research interests and scientific experience to:

shaun.jackson@seattlechildrens.org.

Shaun Jackson Google Scholar profile:
https://scholar.google.com/citations?hl=en&user=I3brhLYAAAAJ

Required Education/Experience:
-Doctorate degree (PhD/DVM/MD) in specialty area from an accredited university training program
- Experience using basic research techniques of specialty area

Required Credentials:
N/A

Preferred:
- Strong background in immunology or cell biology

This compensation range was calculated based on full-time employment (2080 hours worked per calendar year). Offers are determined by multiple factors including equity, skills, experience, and expertise, and may vary within the range provided.

The union pay ranges can be found on the Seattle Children’s website here: WSNA - UFCW

Seattle Children’s offers annual incentive pay based upon performance that is commensurate with the level of the position.

This compensation range is specific to Seattle, positions located outside of Seattle may be compensated differently depending on various factors.

Seattle Children’s offers a generous benefit package, including medical, dental, and vision plans, 403(b), life insurance, paid time off, tuition reimbursement, and more. Click here for more information.

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