Postdoctoral Fellow, CAR T Cell Signaling - Smith Lab

Hope. Care. Cure. These three simple words capture what we do at Seattle Children’s – to help every child live the healthiest and most fulfilling life possible.  Are you ready to engage with a mission-driven organization that is life-changing to many, and touches the hearts of all? #HOPECARECURE

 

As one of the nation's top five pediatric research centers, Seattle Children's Research Institute is dedicated to providing hope, care, and cures to help every child live the healthiest and most fulfilling life possible.

 

Our investigators are involved in hundreds of projects that cover every phase of research, from studying how diseases work to improving investigational therapies. They have pioneered groundbreaking cystic fibrosis treatments and cutting-edge cancer therapies that help a child's immune system defeat cancer, and made other major contributions to pediatric medicine. 

 

Researchers work in close collaboration with one another, their colleagues at partner institutions including the University of Washington and Fred Hutch and our healthcare providers at Seattle Children's Hospital, one of U.S. News & World Report’s top children's hospitals. This collaboration is one of our key strengths, allowing our faculty to draw on a variety of disciplines and techniques as they pursue solutions to some of medicine's most complex problems.

 

We are committed to not only treating disease but to eliminating it. Help us achieve our vision of being a worldwide leader in pediatric research aimed to improve the health and well-being of children. If you are interested in a challenging career aimed at groundbreaking research, Seattle Children's Research Institute is the place for you.

The SEPS lab seeks a postdoctoral research scientist with prior experience in molecular signal transduction, immune cell signaling and/or T cell biology for a full time postdoctoral position the Seattle Children’s Research Institute in downtown Seattle.

 

The R01-funded project involves employing a novel proteomic technology, Quantitative Multiplex co-Immunoprecipitation (QMI) to investigate intracellular signaling pathways activated in response to chimeric antigen receptor (CAR) stimulation. The researcher will be responsible for planning and execution of cell signaling experiments involving both experimental CARs and anti-CD19 clinical products, as well as correlating results to clinical treatment outcomes. Knowledge of and/or experience in T cell biology, CAR T cell production, clinical data management and advanced biostatistics using Matlab and R are all desirable. The ability to work collaboratively and independently in a fast-paced environment is essential.

 

For more information see:

Smith, Neier et al, Science Signaling 2016

Neier, Smith et al, Science Immunology 2019

 

For more information please email Stephen Smith, seps@uw.edu or visit faculty.washington.edu/seps

Required Education/Experience:
-Doctorate degree (PhD/DVM/MD) in specialty area from an accredited university training program
- Experience using basic research techniques of specialty area

Preferred:
- Previous experience conducting research in the pediatric arena
- Experience in protocol and manuscript development and in grant writing

 

In accordance with new Washington law for healthcare workers, Seattle Children’s requires that all staff be fully vaccinated against COVID-19 on or before October 18, 2021, or before beginning employment for start dates after October 18th.

In accordance with Washington state law, Seattle Children’s requires that all employees be fully vaccinated against COVID-19. All offers are contingent and your vaccine status will be verified at onboarding.

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