Research Scientist III

Job ID 2022-44804
Area of Interest
Research & Development
Location Name
1920 Terry
FTE/Hours per pay period
1.0 FTE (80 hours per bi-weekly pay periods)
Work Status
Regular
Department
SC Therapeutics (SCTx)
Shift
Day Shift
Primary Location : City
Seattle
Primary Location : State/Province
WA
Hot Job
No

About Us

Hope. Care. Cure. These three simple words capture what we do at Seattle Children’s – to help every child live the healthiest and most fulfilling life possible.  Are you ready to engage with a mission-driven organization that is life-changing to many, and touches the hearts of all? #HOPECARECURE

 

As one of the nation's top five pediatric research centers, Seattle Children's Research Institute is dedicated to providing hope, care, and cures to help every child live the healthiest and most fulfilling life possible.

 

Our investigators are involved in hundreds of projects that cover every phase of research, from studying how diseases work to improving investigational therapies. They have pioneered groundbreaking cystic fibrosis treatments and cutting-edge cancer therapies that help a child's immune system defeat cancer, and made other major contributions to pediatric medicine. 

 

Researchers work in close collaboration with one another, their colleagues at partner institutions including the University of Washington and Fred Hutch and our healthcare providers at Seattle Children's Hospital, one of U.S. News & World Report’s top children's hospitals. This collaboration is one of our key strengths, allowing our faculty to draw on a variety of disciplines and techniques as they pursue solutions to some of medicine's most complex problems.

 

We are committed to not only treating disease but to eliminating it. Help us achieve our vision of being a worldwide leader in pediatric research aimed to improve the health and well-being of children. If you are interested in a challenging career aimed at groundbreaking research, Seattle Children's Research Institute is the place for you.

Overview

Seattle Children's Therapeutics (SCTx) at Seattle Children's Research Institute (SCRI) is an exciting new venture aimed delivering cutting edge, curative technologies, and therapies to defeat pediatric cancer and beyond. We distinguish ourselves from other research enterprises through our focus on bringing life- saving immunotherapies to the clinic. This position will support the research and development team as we generate high-impact, novel technologies in key areas of development for the next generation of cellular immunotherapies, including gene delivery, targeted gene integration, process innovation, and immune cell engineering. Our work encompasses the inception of new technology, proof of concept development, and the optimization of quality and efficiency for final transfer to the manufacturing team. We implement a fast to kill pipeline that ensures that the best ideas are carried forward. Our aim is the advancement of technology to clinical implementation, and we measure success in clinical outcomes. The nature of our work requires team members who thrive in a team-oriented, challenging, and fast paced environment. Candidates who are motivated by the concept that their individual contributions to a team will have direct clinical impact will be successful in this role.


The primary responsibility for this position is the development of highly engineered cell therapy products. Primary human T cells will be modified by lentivector or CRISPR site-specific editing. Likely lab techniques include operation of Incucyte, liquid handling robots, multiparameter flow cytometry, electroporation optimization, and clinical scale T-cell production. Comfort working within a GLP compliant environment will be an asset. Demonstrated experience handling primary T-cells or other demanding cell types is an advantage. Applicants who can demonstrate diligence in seeking out inefficiencies in their work, determining their causes, and solving these problems with creativity will be given priority. Above all, a willingness to learn, passion for our mission, and creativity are crucial for success at SCTx.


Applicants should have a PhD, or bachelors + 5 years of experience. Candidates from a broad background of experience will be considered to join our multidisciplinary team. Applicants should have an education or work experience related to Immunology, Cell Biology, Molecular Biology, or Bioengineering.


Please include with your CV three references, and a non-generic cover letter describing your unique qualification for the position.

Requirements

Required Education/Experience:


- PhD Degree level in Biochemistry or related field OR
- Master's Degree in Biochemistry or related field plus minimum three (3) years of related experience OR
- Bachelor's Degree or higher in Biochemistry or related field plus minimum five (5) years of related experience with a strong publication record
- Related work experience must include the following:
- Documented experience in Mass Spectrometry-based Proteomics to identify host-factors of microbial infections


Preferred:
- PhD in molecular or cellular biology, biochemistry, neuroscience, or a related area
- Substantial prior experience in biochemistry, molecular biology, and tissue culture techniques
- Familiarity with mouse brain development.

 

In accordance with new Washington law for healthcare workers, Seattle Children’s requires that all staff be fully vaccinated against COVID-19 on or before October 18, 2021, or before beginning employment for start dates after October 18th.

Covid-19 Vaccination

In accordance with Washington state law, Seattle Children’s requires that all employees be fully vaccinated against COVID-19. All offers are contingent and your vaccine status will be verified at onboarding.

Our Commitment to Diversity

Our community welcomes diverse experiences, backgrounds, and thoughts as this is what drives our spirit of inquiry and allows us to better connect with our increasingly diverse patients and families. Our organization recruits, employs, trains, compensates, and promotes without regard to race, religion, color, national origin, gender (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, age, status as a protected veteran, status as an individual with a disability, or other applicable legally protected characteristics.

 

The people who work at Seattle Children’s are members of a community that seeks to respect and celebrate all the qualities that make each of us unique. Each of us is empowered to be ourselves within this community, which cultivates and promotes equity, diversity, and inclusion at all levels.

 

Seattle Children’s is proud to be an Equal Opportunity Workplace and Affirmative Action Employer.

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