Seattle Children's Therapeutics (SCTx) at Seattle Children's Research Institute (SCRI) is an exciting new venture aimed at leveraging a biotech industry business model in a non-profit context to bring cutting edge, curative technologies and therapies to defeat pediatric cancer and beyond. Our immunotherapies offer hope to families who have exhausted other treatment options - our work directly saves lives. We are seeking a bright, enthusiastic, and highly-motivated biologist to join our Research and Development group. This position contributes to a team focused on translating tumor immunotherapy from the bench into pediatric patients with cancer. We look for people who are inspired by our mission and who would fit in well with the collaborative, rigorous, and entrepreneurial spirit of our research team culture.
The primary purpose of this position is to develop and analyze the potential of lentiviral vectors carrying differentially regulated payloads, including chimeric antigen receptors (CARs), to create more efficacious cell therapies for solid tumors. Under the direction of a senior research scientist, the successful candidate will use her/his established molecular and cellular biology skill sets to create both tumor cell lines and primary T cells, and develop and implement assays to assess the cytotoxic and therapeutic potential of the T cell products, both in vitro and in vivo. Lab techniques include basic and advanced molecular biology and operation of Incucyte, MSD, flow cytometers, cell sorters, and liquid handling robots.
The ideal candidate will have significant work experience in flow cytometry, tissue culture, molecular biology, and immunology. The candidate will be extensively involved in designing experiments, implementing new strategies, generating data, analyzing results and preparing reports, in support of funded research studies. To ensure successful project completion and teamwork, she/he must have critical thinking abilities, be able to prioritize and perform multiple tasks in a dynamic environment, meet deadlines, and must have excellent written, verbal, and interpersonal communication skills. The candidate will be required to participate and present data in weekly lab meetings, maintain an up-to-date and well-organized electronic lab notebook, and rigorously follow Good Laboratory Practice (GLP) guidelines. Above all, a willingness to learn, passion for our mission, collaboration, and creativity are crucial for success at Seattle Children's Therapeutics (SCTx).Overall responsibilities include acquiring an in-depth understanding of the field in which they are working, and working with the PI, as well as independently, on the planning, design, execution, trouble-shooting, and interpretation of experiments; makes detailed observations, records data and presents results; assists post docs and fellows in the day-to-day activities and interprets experiments related to assigned projects. The Research Scientist will spend the majority of their time making contributions to on-going laboratory projects, requiring the ability to use independent judgment to address tasks and projects, and will identify and refine existing procedures and practices. The incumbent may also participate in the management of a small rodent colony.
- Bachelor’s Degree in biology, microbiology, immunology, molecular biology or biochemistry.
- Prior experience in a laboratory setting.
- Research experience in biochemistry, molecular biology, and tissue culture techniques is highly preferred.
In accordance with new Washington law for healthcare workers, Seattle Children’s requires that all staff be fully vaccinated against COVID-19 on or before October 18, 2021, or before beginning employment for start dates after October 18th.
Hope. Care. Cure. These three simple words capture what we do at Seattle Children’s – to help every child live the healthiest and most fulfilling life possible. Are you ready to engage with a mission-driven organization that is life-changing to many, and touches the hearts of all? #HOPECARECURE
As one of the nation's top five pediatric research centers, Seattle Children's Research Institute is dedicated to providing hope, care, and cures to help every child live the healthiest and most fulfilling life possible.
Our investigators are involved in hundreds of projects that cover every phase of research, from studying how diseases work to improving investigational therapies. They have pioneered groundbreaking cystic fibrosis treatments and cutting-edge cancer therapies that help a child's immune system defeat cancer, and made other major contributions to pediatric medicine.
Researchers work in close collaboration with one another, their colleagues at partner institutions including the University of Washington and Fred Hutch and our healthcare providers at Seattle Children's Hospital, one of U.S. News & World Report’s top children's hospitals. This collaboration is one of our key strengths, allowing our faculty to draw on a variety of disciplines and techniques as they pursue solutions to some of medicine's most complex problems.
We are committed to not only treating disease but to eliminating it. Help us achieve our vision of being a worldwide leader in pediatric research aimed to improve the health and well-being of children. If you are interested in a challenging career aimed at groundbreaking research, Seattle Children's Research Institute is the place for you.
Our community welcomes diverse experiences, backgrounds, and thoughts as this is what drives our spirit of inquiry and allows us to better connect with our increasingly diverse patients and families. Our organization recruits, employs, trains, compensates, and promotes without regard to race, religion, color, national origin, gender (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, age, status as a protected veteran, status as an individual with a disability, or other applicable legally protected characteristics.
The people who work at Seattle Children’s are members of a community that seeks to respect and celebrate all the qualities that make each of us unique. Each of us is empowered to be ourselves within this community, which cultivates and promotes equity, diversity, and inclusion at all levels.
Seattle Children’s is proud to be an Equal Opportunity Workplace and Affirmative Action Employer.